Increased Whole-Food Flaxseed Supplementation Linked to Improved Liver Fat, Metabolic Health and Gut Microbiota in NAFLD

bowl of flaxseed

Increased Whole-Food Flaxseed Supplementation Linked to Improved Liver Fat, Metabolic Health and Gut Microbiota in NAFLD

Written by Keely Puchalski, ND. Results from a 12-week randomized controlled trial suggest that daily supplementation with 30 g of whole-food flaxseed powder may significantly reduce intrahepatic lipid content, improve body composition, liver function and lipid profiles, while beneficially modulating gut microbiota in obese adults with Non‑alcoholic fatty liver disease (NAFLD).

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The Effect of Astaxanthin After Varicocele Surgery on Antioxidant Status and Semen Quality in Infertile Men: A Triple-Blind Randomized Clinical Trial

Written by Keely Puchalski, ND. Results from this small triple-blind RCT suggest 90 days of astaxanthin (6 mg/day) after varicocelectomy improved sperm motility, increased seminal antioxidant capacity, upregulated NRF2-pathway gene expression, and reduced pro-inflammatory cytokines in infertile men with varicocele, though the study is limited by small sample size, retrospective trial registration, and lack of baseline data and protein-level validation.

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A Comparative Study of Aloe Vera and Thyme Honey Oral Rinse for the Management of Xerostomia in Type 2 Diabetes: Evidence from a Randomized Controlled Trial

Written by Tabish Mehraj, PhD Science Writer. This study evaluated the effectiveness of honey and aloe vera in management of xerostomia over a 4-week period (p=0.002). Both interventions significantly reduced xerostomia symptoms, increased salivary flow rate and improved quality of life as compared to saline (p<0.001), moreover salivary nitric oxide levels were highest in thyme group followed by aloe vera, resulting in enhanced function of the salivary gland. 

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grape seed oil

Grape Seed Extract Improves Cardiovascular and Hepatic Parameters in Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Trial

Written by Tabish Mehraj, PhD, Science Writer. Grape seed extract (GSE) supplementation over two months showed great effectiveness as compared to placebo, the GSE group showed significant improvements in lipid profile (p < 0.05), blood pressure parameters (p < 0.001), insulin resistance markers (p < 0.05), and insulin sensitivity (p < 0.05). Additionally, liver enzyme levels and hepatic steatosis severity were significantly reduced (p < 0.05; p = 0.002). Overall, GSE supplementation showed beneficial metabolic and hepatic effects.

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Alpha-Lipoic Acid Improves Migraine Symptoms and Mitochondrial Markers in Women with Episodic Migraines: Results from a Randomized Controlled Trial

Written by Alexa Heathorn, MS, CNS, Science Writer. Twelve weeks of alpha-lipoic acid supplementation significantly reduced migraine severity, attack frequency, and headache impact while improving markers of mitochondrial metabolism and vascular inflammation in women with episodic migraines.

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AHCC Supplementation Effective in Supporting Immune Function to Clear Human Papillomavirus Infection: Evidence from a Double–Blind Randomized Clinical Trial

Written by Written by Tabish Mehraj, PhD, Science Writer. 3g of AHCC once daily for a 6-month duration resulted in an overall response rate of 58.8% for HPV infection clearance in women with high-risk HPV, showcasing AHCC’s ability to support the host immune system. 

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Short-Chain Fatty Acid–Producing Probiotics Improve Symptoms, Gut Barrier Function, and Inflammation in Adults with Irritable Bowel Syndrome

Written by Alexa Heathorn, MS, CNS, Science Writer. Twice-daily supplementation with a multi-strain Lactobacillus and Bifidobacterium probiotic for 12 weeks significantly reduced IBS symptom severity, increased fecal short-chain fatty acids, improved intestinal barrier integrity, and lowered inflammatory markers in adults across multiple IBS subtypes.

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Zinc Gluconate Improves Appetite and Reduces Pruritus in Hemodialysis Patients: Findings from a Double-Blind Randomized Clinical Trial

Written by Alexa Heathorn, MS, CNS, Science Writer. Daily supplementation with 210 mg of zinc gluconate (30 mg elemental zinc) for 12 weeks improved hunger, desire to eat, prospective food consumption, and reduced pruritus in adults undergoing hemodialysis, without adverse effects or changes in body composition or muscle strength.

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Rhodiola rosea Improves Endurance Performance and Metabolic Efficiency

Written by Taylor Woosley, Science Writer. Findings of a meta-analysis including 26 RCTs featuring 668 healthy participants shows that RR supplementation improved endurance performance, specifically VO2max (p<0.01), TTE (p<0.05), and TTP (p<0.05), reduced muscle damage (CK; p<0.01), while also improving oxidative stress response and antioxidant capacity. 

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