Oleuropein-Enriched Olive Leaf Extract Adjuvant Improves Periodontal Outcomes in the Elderly Population

Oleuropein-Enriched Olive Leaf Extract Adjuvant Improves Periodontal Outcomes in the Elderly Population

Written by Tabish Mehraj, PhD. This study showed that the treatment group achieved greater reductions in ΔPPD and gains in ΔCAL across multiple tooth categories and surfaces. Metabolomic profiling revealed distinct Δ patterns, with 17 metabolites differing between groups. Several, including tentatively identified valine, cinnamic acid, 10‑hydroxy-2-decenoic acid, and cortisol, correlated with periodontal improvements.

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Culinary Doses of Turmeric Are Associated with Improved Self-Reported Pain Ratings in Adults with Chronic Pain

Written by Alexa Heathorn, MS, CNS, Science Writer. In a 21-day randomized crossover trial, adults with moderate chronic pain experienced significant reductions in self-reported pain ratings while consuming culinary amounts of turmeric. However, the addition of black pepper did not provide additional pain-relieving benefits, and no differences were observed between turmeric doses ranging from 300 mg to 3 g daily.

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Mulberry Leaf Extract and Tryptophan Aid in Better Sleep and Mood

Written by Tabish Mehraj, PhD. The supplement significantly improved sleep quality, reduced sleep onset latency by approximately 3.8 minutes, and enhanced feelings of relaxation and vigor. It also improved glucose regulation by lowering the 1-hour postprandial glucose response by 21% and peak glucose concentrations by 16%. However, no significant effects on cognitive performance were observed.

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5-Hydroxytryptophan Supplement’s Effect on Cognitive and Mood Function in an Elderly Asian Population

Written by Tabish Mehraj, PhD. This study showed that 5-HTP supplementation led to modest cognitive improvements, showing a significant rise in total MoCA scores over 12 weeks. The supplement demonstrated a potential antidepressant effect, as participants showed a significant reduction in depressive symptoms by the eighth week. Since no changes were observed in neurodegeneration biomarkers, the observed benefits are likely attributable to enhanced serotonergic activity rather than structural brain changes.

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Proprietary Ashwagandha-Based Herbal Formula Improves Stress, Anxiety, Mood, and Well-Being in Adults with Moderate Stress

Written by Alexa Heathorn, MS, CNS, Science Writer. Eight weeks of supplementation with a proprietary herbal formulation containing ashwagandha, Triphala, and Trikatu significantly improved perceived stress, anxiety, mood, and overall well-being compared with both ashwagandha root extract alone and placebo, while demonstrating a favorable safety profile in adults experiencing moderate stress and anxiety.

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Alpha‑Lipoic Acid Supplement: Effect on Vascular Function and Inflammation Markers in Patients with Stroke

Written by Tabish Mehraj, PhD, Science Writer. This study demonstrated successful randomization and comparable baseline characteristics between the alpha-lipoic acid and placebo groups. After 12 weeks of supplementation, the ALA group showed significant vascular improvements, including a marked reduction in carotid intima-media thickness (CIMT) and a substantial increase in Flow-Mediated Dilation (FMD) compared to the placebo group. It significantly lowered serum hs-CRP levels; its impact on other inflammatory cytokines, such as TNF-α and IL-6, remained limited.

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A Dose-Response Meta-Analysis of Melatonin for Cardio-Metabolic Risk Factors

Written by Tabish Mehraj, PhD. Melatonin supplementation enhances cardiovascular and liver health by optimizing lipid profiles, reducing systolic blood pressure, and lowering ALT levels. It also exerts potent anti-inflammatory and antioxidant effects by decreasing markers such as CRP and MDA, while boosting total antioxidant capacity. These findings underscore its potential in managing metabolic risks and systemic inflammation.

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Standardized Holy Basil Extract (Holixer™, 250 mg/day) Improves Stress and Sleep Outcomes and Reduces Cortisol Reactivity in Stressed Adults: Evidence from an 8-Week RCT

Written by Keely Puchalski, ND. Results from this trial suggest that 8 weeks of supplementation with a standardized Ocimum tenuiflorum extract (Holixer™) at 250 mg/day reduced perceived stress and improved subjective sleep quality compared to placebo in adults experiencing stress and poor sleep.

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