Astaxanthin Improves Oxidative Stress Markers, Uric Acid, and Clinical Symptoms in Patients with Heart Failure: Results from a Randomized Controlled Trial

Top view of stethoscope and heartbeat

Astaxanthin Improves Oxidative Stress Markers, Uric Acid, and Clinical Symptoms in Patients with Heart Failure: Results from a Randomized Controlled Trial

Written by Alexa Heathorn, MS, CNS. Daily supplementation with 20 mg of astaxanthin for 8 weeks significantly increased antioxidant capacity (TAC, SOD), reduced oxidative stress (MDA) and uric acid levels, and improved fatigue and dyspnea in patients with heart failure, supporting its potential role as an adjunct therapy for cardiometabolic and symptom management.

Read more
almonds in bowl

Almonds: A Great Snack Option for Individuals with Metabolic Syndrome

Written by Tabish Mehraj, PhD, Science Writer. This study showed that almond consumption reduced total cholesterol and LDL-C, with about 29% of participants showing a drop of at least 22 mg/dL. Daily vitamin E intake increased from ~5 mg to over 17 mg, along with improved antioxidant metabolite levels and reduced gut inflammation markers (over 20 μg/g reduction in many cases). It also improved nutrient intake (fiber, magnesium, healthy fats) without increasing body weight, resulting in a small reduction in waist circumference of ~0.8 cm at 4 weeks.

Read more
Ashwagandha or Aswaganda OR Indian Ginseng is an Ayurveda medicine in stem and powder form

Ashwagandha Improves Triglycerides and VLDL Levels in Adults with Overweight and Obesity

Written by Alexa Heathorn, MS, CNS. Daily supplementation with 500 mg of Ashwagandha for 40 days significantly reduced triglyceride and VLDL-c levels, with no significant changes in body weight or overall body composition, suggesting a targeted effect on lipid metabolism in adults with overweight and obesity.

Read more
Fresh lemon with vibrant yellow color, sliced to reveal juicy interior and seeds, accompanied by green leaves

Impact of a Food Supplement on Glucose and Lipid Metabolism

Written by Tabish Mehraj, PhD, Science Writer. This study evaluated the tolerability and efficacy of a food supplement containing citrus lemon extracts in individuals with impaired fasting glycemia (IFG). The treatment group showed significant improvements in fasting-state glycemia after 3 months, with normalization of glucose levels (p<0.001 vs T0), unlike the placebo group. Improvements were also observed in the overall lipid profile. 

Read more
Pile of blueberry fruit in a bowl plate on a tray over gray cement concrete background, close up, healthy eating design concept.

Blueberries and Your Gut: How a Daily Berry Habit Reshapes Your Microbiome

Written by Tabish Mehraj, PhD, Science Writer. This study evaluated the effects of blueberry consumption, which may upregulate the ability of the geriatric human gut to use dietary polyphenols by changing the fecal microbiome. It led to the reductions in HDL and APoA-I. These findings suggest that blueberries target specific beneficial gut bacteria, offering unique advantages when combined with exercise, but their overall metabolic impact warrants further investigation.

Read more
Happy Senior Couple Shopping for Fresh Vegetables

Urolithin A Improves Immune Cell Function and Mitochondrial Health in Middle-Aged Adults: Results from a Randomized Controlled Trial

Written by Alexa Heathorn, MS, CNS. Four weeks of daily urolithin A supplementation (1,000 mg) improved immune cell composition, increased naïve CD8⁺ T cells, enhanced mitochondrial function, and reduced markers of immune exhaustion in healthy middle-aged adults, supporting its potential role in promoting immune resilience and healthy aging.

Read more
happy children group in school

Nettle Extract and Metabolic Outcomes in Obese Children: A Randomized Controlled Trial

Written by Tabish Mehraj, PhD, Science Writer. In this parallel randomized controlled trial, 64 children aged 12–18 years with obesity were randomly assigned to receive either nettle syrup twice daily, plus a prescribed diet, or diet alone for 12 weeks. Demographic, metabolic, and lipid parameters were assessed and analyzed using IBM SPSS Statistics v24.0 (P < 0.05). Most participants in both groups were girls. After eight weeks, significant intergroup differences were observed in fasting blood sugar (FBS) (P = 0.043), Low Density Lipoprotein (LDL) (P = 0.023), and Homeostatic Model Assessment for Insulin Resistance HOMA-IR (P = 0.025). At week 12, FBS remained significantly higher in the intervention group (P = 0.044) but stayed within the normal range.

Read more
olive leaf extract

Olive Leaf Extract Improves Postmenopausal Symptoms: A Randomized Double-Blind Trial

Written by Tabish Mehraj, PhD, Science Writer. This study evaluated the effects of olive leaf extract (OLE) supplementation in postmenopausal women for 12 weeks. The OLE group showed a significant improvement in overall Menopause-Specific Quality of Life (MENQoL) scores compared with placebo (p = 0.027). A significant increase in Bone Mineral Density BMD (p = 0.019) was observed. OLE also significantly reduced serum triglycerides (p = 0.010), with no significant changes in cholesterol levels, body composition, or handgrip strength. 

Read more
bowl of flaxseed

Increased Whole-Food Flaxseed Supplementation Linked to Improved Liver Fat, Metabolic Health and Gut Microbiota in NAFLD

Written by Keely Puchalski, ND. Results from a 12-week randomized controlled trial suggest that daily supplementation with 30 g of whole-food flaxseed powder may significantly reduce intrahepatic lipid content, improve body composition, liver function and lipid profiles, while beneficially modulating gut microbiota in obese adults with Non‑alcoholic fatty liver disease (NAFLD).

Read more
man smiling

The Effect of Astaxanthin After Varicocele Surgery on Antioxidant Status and Semen Quality in Infertile Men: A Triple-Blind Randomized Clinical Trial

Written by Keely Puchalski, ND. Results from this small triple-blind RCT suggest 90 days of astaxanthin (6 mg/day) after varicocelectomy improved sperm motility, increased seminal antioxidant capacity, upregulated NRF2-pathway gene expression, and reduced pro-inflammatory cytokines in infertile men with varicocele, though the study is limited by small sample size, retrospective trial registration, and lack of baseline data and protein-level validation.

Read more
Back To Top