Written by Tabish Mehraj, PhD. In this cross-sectional study of 2,044 participants (median age, 69 years; 61.1% women), plasma vitamin C levels were significantly and independently associated with the GMV/ICV ratio and DMN connectivity (both p < 0.001).
Written by Alexa Heathorn, MS, CNS. Daily consumption of one avocado for six months significantly reduced dietary glycemic load without significantly changing dietary glycemic index, suggesting a simple dietary strategy for lowering the glycemic impact of the diet in adults with abdominal obesity.
Written by Chrystal Moulton, Science Writer. Results from this study demonstrated that the WS-35 formulation (480 mg standardized to 35% withanolide glycosides and delivering 185 mg total withanolides) achieved the highest bioavailability of withanolide A, withaferin A, withanoside IV, and total withanolides among the four tested extracts.
Written by Tabish Mehraj, PhD. In this study, ashwagandha root extract supplementation significantly improved processing speed (p=0.040), delayed word recall (p=0.038, d=0.59), Stroop accuracy (p=0.021, d=0.61), Corsi span (p=0.013, d=0.66), and choice reaction time accuracy (p=0.005, d=0.75), alongside better parent-reported sleep (SDSC, p=0.035), with no significant adverse events.
Written by Tabish Mehraj, PhD. In this study, crocin significantly improved Follicle-stimulating hormone levels (P = 0.048) and reduced hirsutism, as measured by the Ferriman–Gallwey score (P = 0.042), by day 90. It also significantly improved acne severity (P = 0.03), with no patients in the crocin group having severe acne at the end of the study. However, crocin did not significantly improve fasting blood sugar.
Written by Jessica Patella, ND. This abstract suggests zinc supplementation can improve zinc levels, GI symptoms in IBS, and reduce depression and stress scores.
Written by Tabish Mehraj, PhD. In this study, a significant increase in bioavailability with micellar formulation was observed, with 18.9-fold higher Cmax (95% CI: 1.9–30.7 ng/mL vs. 74.4–288.3 ng/mL; p = 0.007) vs. 178–612.5 ng·h/mL; p = 0.015). Tmax was 0.5 (95% CI:0.5–4.0) hours for the micellar formulation versus 2.5 (95% CI: 0.5–8.0) hours. No adverse events were observed in either group. Compared to the standard, the micellar formulation showed superior pharmacokinetic outcomes.
Written by Tabish Mehraj, PhD. In this study, the headache intensity was 1.37 ± 1.10 with lavender and 2.50 ± 2.43 in the control group, while no headaches were reported with acetaminophen. Headache severity differed significantly among groups (p < 0.001), and comfort was significantly higher with both acetaminophen and lavender than with control (p < 0.001).
Written by Alexa Heathorn, CNS. Daily supplementation with 1,500 mg of curcumin for 14 weeks significantly improved blood pressure, LDL-C, HDL-C, inflammation, and ASCVD risk classification compared with conventional therapy alone in adults with type 2 diabetes and elevated cardiovascular risk.
Written by Tammy Mish, CN, CMTA. This informative article breaks down the key sections of a supplement label, helping you understand what they mean so you can make informed purchasing decisions with confidence.
