A Dose-Response Meta-Analysis of Melatonin for Cardio-Metabolic Risk Factors

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A Dose-Response Meta-Analysis of Melatonin for Cardio-Metabolic Risk Factors

Written by Tabish Mehraj, PhD. Melatonin supplementation enhances cardiovascular and liver health by optimizing lipid profiles, reducing systolic blood pressure, and lowering ALT levels. It also exerts potent anti-inflammatory and antioxidant effects by decreasing markers such as CRP and MDA, while boosting total antioxidant capacity. These findings underscore its potential in managing metabolic risks and systemic inflammation.

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Standardized Holy Basil Extract (Holixer™, 250 mg/day) Improves Stress and Sleep Outcomes and Reduces Cortisol Reactivity in Stressed Adults: Evidence from an 8-Week RCT

Written by Keely Puchalski, ND. Results from this trial suggest that 8 weeks of supplementation with a standardized Ocimum tenuiflorum extract (Holixer™) at 250 mg/day reduced perceived stress and improved subjective sleep quality compared to placebo in adults experiencing stress and poor sleep.

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Curcuma longa and Boswellia serrata Extract: Modulation of Affective and Sensory Qualities of Acute Nociceptive Pain

Written by Tabish Mehraj, PhD. In this study, the treatment achieved a rapid 98% reduction in pain within 6 hours, significantly outperforming placebo (p < 0.001) and resulting in near-total improvement in VAS and PPI scores. Common pain descriptors like “tender” were virtually eliminated, resulting in comprehensive and substantial relief across all body regions. 

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Safety and Efficacy of Shatavari Root Extract for the Management of Menopausal Symptoms

Written by Tabish Mehraj, PhD, Science Writer. In this study Shatavari extract significantly improved menopausal symptoms, including emotional, social, and physical well-being, compared to placebo. Women taking Shatavari showed notable reductions in anxiety, depression, stress, and vasomotor symptoms such as hot flashes and night sweats. Sleep quality also improved, with better duration and fewer disturbances. Hormonal analysis indicated increased estradiol and progesterone levels, suggesting support for hormonal balance during menopause.

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Modified Boswellia and Curcumin Formulations Improve Pain and Joint Function in Knee Osteoarthritis

Written by Alexa Heathorn, CNS, Science Writer. A network meta-analysis of 20 randomized controlled trials found that enhanced bioavailability formulations of Boswellia serrata and Curcuma longa significantly improved pain, stiffness, and knee function in individuals with knee osteoarthritis, with modified boswellia formulations showing the most consistent functional benefits and no significant increase in adverse effects.

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A Blend of Ginger and Vitex (Muvz™) Improves Joint Mobility and Physical Function in Adults with Moderate Joint Pain

Written by Tabish Mehraj, PhD, Science Writer. E-PR-01 significantly improved musculoskeletal health, joint mobility, and physical function in a dose-dependent manner over 90 days, with the high-dose group achieving clinically significant benefits. Participants also experienced notable reductions in joint and low-back pain and improvements in quality of life. The supplement was safe and well-tolerated, with no serious adverse effects reported.

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Ashwagandha (Withania somnifera) Root Extract’s Effect on Weight Management and Stress  

Written by Tabish Mehraj, PhD, Science Writer. In this study, ashwagandha supplementation led to a significant reduction in BMI (3.31 kg/m²) and weight loss (8.46 kg) compared with placebo; it also helped reduce stress (PSS-10), improved quality of life, and controlled food cravings. Serum cortisol levels decreased by 36%; the treatment was well tolerated, with mild side effects.

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Hair Growth and Reduction in Hair Fall Associated with Saw Palmetto (Serenoa repen) Extracts

Written by Tabish Mehraj, PhD, Science Writer. This study evaluated the effects of a proprietary Saw palmetto extract, which significantly increased the hair growth counts and improved overall hair density compared to placebo (p < 0.004). A 70.7% decrease in hair shedding was observed in a subgroup of women. Overall, results show statistically significant improvements in hair growth and retention versus placebo.

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