Written by Alexa Heathorn, MS, CNS. Four weeks of daily urolithin A supplementation (1,000 mg) improved immune cell composition, increased naïve CD8⁺ T cells, enhanced mitochondrial function, and reduced markers of immune exhaustion in healthy middle-aged adults, supporting its potential role in promoting immune resilience and healthy aging.
Written by Tabish Mehraj, PhD, Science Writer. In this parallel randomized controlled trial, 64 children aged 12–18 years with obesity were randomly assigned to receive either nettle syrup twice daily, plus a prescribed diet, or diet alone for 12 weeks. Demographic, metabolic, and lipid parameters were assessed and analyzed using IBM SPSS Statistics v24.0 (P < 0.05). Most participants in both groups were girls. After eight weeks, significant intergroup differences were observed in fasting blood sugar (FBS) (P = 0.043), Low Density Lipoprotein (LDL) (P = 0.023), and Homeostatic Model Assessment for Insulin Resistance HOMA-IR (P = 0.025). At week 12, FBS remained significantly higher in the intervention group (P = 0.044) but stayed within the normal range.
Written by Tabish Mehraj, PhD, Science Writer. This study evaluated the effects of olive leaf extract (OLE) supplementation in postmenopausal women for 12 weeks. The OLE group showed a significant improvement in overall Menopause-Specific Quality of Life (MENQoL) scores compared with placebo (p = 0.027). A significant increase in Bone Mineral Density BMD (p = 0.019) was observed. OLE also significantly reduced serum triglycerides (p = 0.010), with no significant changes in cholesterol levels, body composition, or handgrip strength.
Written by Keely Puchalski, ND. Results from a 12-week randomized controlled trial suggest that daily supplementation with 30 g of whole-food flaxseed powder may significantly reduce intrahepatic lipid content, improve body composition, liver function and lipid profiles, while beneficially modulating gut microbiota in obese adults with Non‑alcoholic fatty liver disease (NAFLD).
Written by Keely Puchalski, ND. Results from this small triple-blind RCT suggest 90 days of astaxanthin (6 mg/day) after varicocelectomy improved sperm motility, increased seminal antioxidant capacity, upregulated NRF2-pathway gene expression, and reduced pro-inflammatory cytokines in infertile men with varicocele, though the study is limited by small sample size, retrospective trial registration, and lack of baseline data and protein-level validation.
Written by Tabish Mehraj, PhD Science Writer. This study evaluated the effectiveness of honey and aloe vera in management of xerostomia over a 4-week period (p=0.002). Both interventions significantly reduced xerostomia symptoms, increased salivary flow rate and improved quality of life as compared to saline (p<0.001), moreover salivary nitric oxide levels were highest in thyme group followed by aloe vera, resulting in enhanced function of the salivary gland.
Written by Tabish Mehraj, PhD, Science Writer. Grape seed extract (GSE) supplementation over two months showed great effectiveness as compared to placebo, the GSE group showed significant improvements in lipid profile (p < 0.05), blood pressure parameters (p < 0.001), insulin resistance markers (p < 0.05), and insulin sensitivity (p < 0.05). Additionally, liver enzyme levels and hepatic steatosis severity were significantly reduced (p < 0.05; p = 0.002). Overall, GSE supplementation showed beneficial metabolic and hepatic effects.
Written by Alexa Heathorn, MS, CNS, Science Writer. Twelve weeks of alpha-lipoic acid supplementation significantly reduced migraine severity, attack frequency, and headache impact while improving markers of mitochondrial metabolism and vascular inflammation in women with episodic migraines.
Written by Written by Tabish Mehraj, PhD, Science Writer. 3g of AHCC once daily for a 6-month duration resulted in an overall response rate of 58.8% for HPV infection clearance in women with high-risk HPV, showcasing AHCC’s ability to support the host immune system.
Written by Alexa Heathorn, MS, CNS, Science Writer. Twice-daily supplementation with a multi-strain Lactobacillus and Bifidobacterium probiotic for 12 weeks significantly reduced IBS symptom severity, increased fecal short-chain fatty acids, improved intestinal barrier integrity, and lowered inflammatory markers in adults across multiple IBS subtypes.
