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Multi-Strain Probiotic Improve Gut Barrier Integrity, Reduce Oxidative Stress, and Lower Inflammation in Undernourished Adults

Written by Alexa Heathorn, MS, CNS, Science Writer. Eight weeks of supplementation with a multi-strain probiotic combined with an energy-surplus diet significantly improved serum zonulin, reduced markers of oxidative stress and systemic inflammation, and enhanced biomarkers of gut barrier function in undernourished adults compared with diet alone.

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almonds in bowl

Almond Supplementation for Improved Acne Lesions and Skin Health

Written by Tabish Mehraj, PhD. At 20 weeks, the almond group showed greater improvements in acne outcomes than controls, with total lesion counts reduced by −22.2% vs. −9.8%, inflammatory lesions by −8.3% vs. +12%, and non-inflammatory lesions by −26.1% vs. −20.4%. Objective lesion severity also decreased significantly (p ≤ 0.001), including reductions in lesion volume, area, and height. In addition, almond consumption increased skin microbial diversity (Shannon index: 2.6 → 3.4, p = 0.039; Chao1 index: 266.9 → 835.2, p < 0.001) and improved acne-related quality of life (p < 0.001) and anxiety symptoms (p = 0.016).

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Ashwagandha or Aswaganda OR Indian Ginseng is an Ayurveda medicine in stem and powder form

Ashwagandha Root Extract (KSM-66) and Male Sexual Health: Evidence from an 8-Week Randomized Controlled Trial

Written by Keely Puchalski, ND. Results from this 8-week prospective, randomized, double-blind, placebo-controlled, parallel-group trial suggest that 300 mg twice daily of standardized ashwagandha root extract (KSM-66) improved self-reported sexual desire, erectile function, and semen parameters in men with mild-to-moderate sexual dysfunction compared to placebo, though methodological inconsistencies and data quality concerns limit confidence in the magnitude and generalizability of the findings.

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Oleuropein-Enriched Olive Leaf Extract Adjuvant Improves Periodontal Outcomes in the Elderly Population

Written by Tabish Mehraj, PhD. This study showed that the treatment group achieved greater reductions in ΔPPD and gains in ΔCAL across multiple tooth categories and surfaces. Metabolomic profiling revealed distinct Δ patterns, with 17 metabolites differing between groups. Several, including tentatively identified valine, cinnamic acid, 10‑hydroxy-2-decenoic acid, and cortisol, correlated with periodontal improvements.

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low back pain

Culinary Doses of Turmeric Are Associated with Improved Self-Reported Pain Ratings in Adults with Chronic Pain

Written by Alexa Heathorn, MS, CNS, Science Writer. In a 21-day randomized crossover trial, adults with moderate chronic pain experienced significant reductions in self-reported pain ratings while consuming culinary amounts of turmeric. However, the addition of black pepper did not provide additional pain-relieving benefits, and no differences were observed between turmeric doses ranging from 300 mg to 3 g daily.

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Mulberry Leaf Extract and Tryptophan Aid in Better Sleep and Mood

Written by Tabish Mehraj, PhD. The supplement significantly improved sleep quality, reduced sleep onset latency by approximately 3.8 minutes, and enhanced feelings of relaxation and vigor. It also improved glucose regulation by lowering the 1-hour postprandial glucose response by 21% and peak glucose concentrations by 16%. However, no significant effects on cognitive performance were observed.

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